Read more about our offers and requirements. In an interdisciplinary research approach we address the effects of hormones derived from adipose tissue adipokines on CNS function and, in turn, the control of adipose tissue and body weight by the brain.
Adipocytes secrete bioactive factors that act in an autocrine, paracrine, or endocrine manner similar to the cytokine peptides of the immune system, thus termed adipokines. Since the Lady b Lubeck of the first adipokine, leptin, a growing number of such fat cell-derived peptide hormones has been described including adiponectin, nesfatin-1, or visfatin; but also inflammatory cytokines and steroid hormones.
Adipokines signal the adipose state to appetite-regulating centres of the brain. In the hypothalamusleptin inhibits appetite-promoting neurons in the arcuate nucleus and promotes energy expenditure via stimulation of sympathetic nerve Singles Bad Salzuflen ltd to adipose tissues.
Such feedback mechanisms also exist for other adipokines. The complex autoregulatory feedback system between central and adipose tissues is essentially involved in adjusting setpoints of energy homeostasis. Organization People Jobs.
Projects International Partners Publications. During my lab stay I will investigate circadian rhythms of white adipose tissue, wrist temperature, and activity as predictors for weight-loss efficiency by bariatric surgery.
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